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Thread: can you get high off Lyrica ?

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    Home › Drugs by Condition › F › Fibromyalgia › Lyrica › Dosage
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    Lyrica Dosage

    Generic name: pregabalin
    Dosage form: capsules
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    This dosage information does not include all the information needed to use Lyrica safely and effectively. See full prescribing information for Lyrica.

    The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
    Dosage and Administration for Lyrica


    LYRICA is given orally with or without food.

    When discontinuing LYRICA, taper gradually over a minimum of 1 week.
    Neuropathic pain associated with diabetic peripheral neuropathy

    The maximum recommended dose of LYRICA is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Begin dosing at 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Because LYRICA is eliminated primarily by renal excretion, adjust the dose in patients with reduced renal function [see Dosage and Administration (2.6)].

    Although LYRICA was also studied at 600 mg/day, there is no evidence that this dose confers additional significant benefit and this dose was less well tolerated. In view of the dose-dependent adverse reactions, treatment with doses above 300 mg/day is not recommended [see Adverse Reactions (6.1)].
    Postherpetic neuralgia

    The recommended dose of LYRICA is 75 to 150 mg two times a day, or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Begin dosing at 75 mg two times a day, or 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Because LYRICA is eliminated primarily by renal excretion, adjust the dose in patients with reduced renal function [see Dosage and Administration (2.6)].

    Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg/day, and who are able to tolerate LYRICA, may be treated with up to 300 mg two times a day, or 200 mg three times a day (600 mg/day). In view of the dose-dependent adverse reactions and the higher rate of treatment discontinuation due to adverse reactions, reserve dosing above 300 mg/day for those patients who have on-going pain and are tolerating 300 mg daily [see Adverse Reactions (6.1)].
    Adjunctive therapy for adult patients with partial onset seizures

    LYRICA at doses of 150 to 600 mg/day has been shown to be effective as adjunctive therapy in the treatment of partial onset seizures in adults. Both the efficacy and adverse event profiles of LYRICA have been shown to be dose-related. Administer the total daily dose in two or three divided doses. In general, it is recommended that patients be started on a total daily dose no greater than 150 mg/day (75 mg two times a day, or 50 mg three times a day). Based on individual patient response and tolerability, the dose may be increased to a maximum dose of 600 mg/day.

    Because LYRICA is eliminated primarily by renal excretion, adjust the dose in patients with reduced renal function [see Dosage and Administration (2.6)].

    The effect of dose escalation rate on the tolerability of LYRICA has not been formally studied.

    The efficacy of add-on LYRICA in patients taking gabapentin has not been evaluated in controlled trials. Consequently, dosing recommendations for the use of LYRICA with gabapentin cannot be offered.
    Management of Fibromyalgia

    The recommended dose of LYRICA for fibromyalgia is 300 to 450 mg/day. Begin dosing at 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day). Although LYRICA was also studied at 600 mg/day, there is no evidence that this dose confers additional benefit and this dose was less well tolerated. In view of the dose-dependent adverse reactions, treatment with doses above 450 mg/day is not recommended [see Adverse Reactions (6.1)]. Because LYRICA is eliminated primarily by renal excretion, adjust the dose in patients with reduced renal function [see Dosage and Administration (2.6)].
    Adjunctive treatment of Generalized Anxiety Disorder

    The recommended dose range of LYRICA as an adjunctive treatment of GAD is 150 to 600 mg/day. The recommended starting dose is 75 mg two times a day (150 mg/day) and may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. For patients who do not experience sufficient benefit with 300 mg/day, the dose may be increased to a maximum of 300 mg two times a day (600 mg/day). Because LYRICA is eliminated primarily by renal excretion, the dose should be adjusted for patients with reduced renal function [creatinine clearance less than 60 mL/min – see Patients with Renal Impairment (2.6)].
    Patients with Renal Impairment

    In view of dose-dependent adverse reactions and since LYRICA is eliminated primarily by renal excretion, adjust the dose in patients with reduced renal function. Base the dose adjustment in patients with renal impairment on creatinine clearance (CLcr), as indicated in Table 1. To use this dosing table, an estimate of the patient's CLcr in mL/min is needed. CLcr in mL/min may be estimated from serum creatinine (mg/dL) determination using the Cockcroft and Gault equation:
    Image from Drug Label Content

    Next, refer to the Dosage and Administration section to determine the recommended total daily dose based on indication, for a patient with normal renal function (CLcr ?60 mL/min). Then refer to Table 1 to determine the corresponding renal adjusted dose.

    (For example: A patient initiating LYRICA therapy for postherpetic neuralgia with normal renal function (CLcr ?60 mL/min), receives a total daily dose of 150 mg/day pregabalin. Therefore, a renal impaired patient with a CLcr of 50 mL/min would receive a total daily dose of 75 mg/day pregabalin administered in two or three divided doses.)

    For patients undergoing hemodialysis, adjust the pregabalin daily dose based on renal function. In addition to the daily dose adjustment, administer a supplemental dose immediately following every 4-hour hemodialysis treatment (see Table 1).
    Table 1. Pregabalin Dosage Adjustment Based on Renal Function Creatinine Clearance (CLcr)
    (mL/min) Total Pregabalin Daily Dose (mg/day)* Dose Regimen
    TID= Three divided doses; BID = Two divided doses; QD = Single daily dose.

    *
    Total daily dose (mg/day) should be divided as indicated by dose regimen to provide mg/dose.

    Supplementary dose is a single additional dose.

    .60 150 300 450 600 BID or TID
    30–60 75 150 225 300 BID or TID
    15–30 25–50 75 100–150 150 QD or BID
    <15 25 25–50 50–75 75 QD
    Supplementary dosage following hemodialysis (mg)†
    Patients on the 25 mg QD regimen: take one supplemental dose of 25 mg or 50 mg
    Patients on the 25–50 mg QD regimen: take one supplemental dose of 50 mg or 75 mg
    Patients on the 50–75 mg QD regimen: take one supplemental dose of 75 mg or 100 mg
    Patients on the 75 mg QD regimen: take one supplemental dose of 100 mg or 150 mg
    Oral Solution Concentration and Dispensing

    The oral solution is 20 mg pregabalin per milliliter (mL) and prescriptions should be written in milligrams (mg). The pharmacist will calculate the applicable dose in mL for dispensing (e.g., 150 mg equals 7.5 mL oral solution)

  2. #2

    lyrica is like mild ecstacy

    i get high off lyrica but you need to really amp up the dose i snort my lyrica its the best shit out there i love getting totally high off it and its cheap and everywhere! I wonder how many people still have no clue how good lyrica is to get high.

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